Critères d'inclusion : - Patient aged 18 years old
- Carcinoma oral cavity, pharyngolaryngeal or without lymphadenopathy door
- Patient treated by one of the following diagrams:
-> radiotherapy alone
-> postoperative radiotherapy + / - sensitized platinum (cisplatin or carboplatin)
-> a chemoradiation 5-FU and platinum (the Cetuximab is not allowed)
-> diagram organ preservation (induction chemotherapy and radiotherapy in responders)
- Untreated patients
- Patient should receive conventional radiotherapy or tomotherapy
- Adapted stomatological care
- Life expectancy > 3 months
- WHO score < 2
- Patient stable, not having the time of the examination of evidence of recurrent or progressive malignancy other
- For patients with an indication of chemotherapy combined with radiotherapy,biological assessments compatible with chemotherapy:
-> WBC > 3000/mm3
-> Polynuclear > 2000/mm3
-> Platelets > 150,000/mm3
-> Creatinine less than 2 times normal
-> Bilirubin less than 2.5 times normal
- Patient fluent in French
- Affiliation to a system of social security
- Patient has given written consent
Critères de non-inclusion : - Patient with a history of malignancy, outside a basal cell carcinoma or cervical cancer treated and cured
- Patient has at the time of examination signs of recurrence or other neoplasia scalable
- Patient with a history of prior chemotherapy or radiation therapy with the exception of the scheme of organ preservation (induction chemotherapy before radiation)
- For patients with an indication of chemotherapy combined with radiotherapy, contraindication to treatment with specific platinum (cisplatin or carboplatin) with or without 5 Fluorouracil
- Infectious diseases uncontrolled
- Patient is pregnant or lactating or absence of contraception during their reproductive
- Patient hypertensive unbalanced under antihypertensive treatment
- Uncontrolled cardiac disease
- Patients with renal or hepatic
- Known allergy to any component of Ialuset ®
- Patient deprived of liberty under guardianship
- Any medical condition or psychological associate that could compromise the patient's ability to participate in the study
- Inability to undergo medical test for geographical, social or psychological