Critères d'inclusion : - All patients expected to be treated with aflibercept in combination with FOLFIRI for a mCRC, after failure of treatment with oxaliplatin + anti-EGFR on the decision of the doctor (situation included in the framework of the MA of aflibercept) .
- Age ≥18 years
- Signature of the agreement for the collection of medical and personal data. (Patients who have received FOLFIRINOX in the first line metastatic are allowed) Note: Failure is defined as progression during or within 6 months after discontinuation of oxaliplatin
Critères de non-inclusion : - Concurrent participation in a clinical trial
- Patients who have previously received anti-VEGF agents and / or aflibercept in one trial.
- Patients who received FOLFIRI in the first metastatic line.