Critères d'inclusion : - ≥ 18 and ≤ 65 years
- Good performance status, ECOG 0 or 1 (39).
- Histologically proved adenocarcinoma in colon or rectum
- BRAF wild-type CRC on primary tumor or liver metastases
- High standard oncological surgical resection of the primary defined by :
Safe margin of resection
Curative resection of primary tumor according to oncological principles
TNM adequate staging
- Absence of local recurrence on colonoscopy (within 12 months before inclusion)
- Confirmed non resectable colorectal liver metastases by the validation committee
- ≥ 3 months of tumor control during the last chemotherapy line: Stable or Partial Response on RECIST criteria (40)
- ≤ 2 lines of chemotherapy for metastatic disease
- CEA < 80 microg/L or a decrease ≥ 50% of the highest serum CEA levels observed during the disease
- Absence of extrahepatic tumor localisation according to CT scan and PET-CT
- Renal function should be within the normal limits
- No need for extra-renal purification procedure, hemodialysis or kidney transplantation associated (nephrologist assessment)
- A platelet count> 80,000 / mm3
- White blood cell count> 2500 / mm3
- Eligible for both treatments groups
- Signed informed consent and expected cooperation of the patient for the treatment and follow up
Critères de non-inclusion : - Participation refusal
- No health insurance facilities
- General contraindication to LT (Severe cardiopulmonary disease or other life-limiting coexisting medical conditions, extrahepatic malignancy, active alcohol or substance abuse, active infection or uncontrolled sepsis, lack of psychosocial support or inability to comply with medical treatment)
- Other malignancies either concomitant or within 5 years before liver transplantation
- Patients not having received standard treatment for the primary CRC according to recommended guidelines
- Prior extra hepatic metastatic disease or local relapse
- Pregnancy at the time of inclusion