Schéma : The purpose of this study is to evaluate the performances of the real-time PCR ADEMTECH kit of DNA extraction and detection of Aspergillus fumigatus in serum samples in patients at high-risk for invasive aspergillosis (IA). DNA detection will be associated with detection of TR34/L98H mutations in cyp51A gene, which confer azole resistance.
Hematological patients at high risk for invasive aspergillosis
Intervention: Diagnostic Test: DNA extraction and detection of Aspergillus fumigatus in serum samples
Current primary outcome:
Performance of PCR for Aspergillosis diagnosis [ Time Frame: 6 months ]
Determination of the performances (Sensitivity, specificity, PPV and NPV) of the kit
Current secondary outcome:
Detection of azole resistance [ Time Frame: 6 months ]
Detection of TR34 and L98H mutations in the A. fumigatus single-copy number gene cyp51A.
Phase : NA
Stade : NA
1 (hémato), Rechute, Réfractaire